We publish on topics across biomedicine

Publications

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The transcriptional response to lung-targeting lipid nanoparticles in vivo

Radmand A, Lokugamage MP, Kim H, Dobrowolski CN, Zenhausern R, Loughrey D, Huayamares SG, Hatit MCZ, Ni H, Del Cid A, Da Silva Sanchez AJ, Paunovska K, Echeverri ES, Shajii A, Peck H, Santangelo PJ, Dahlman JE.

Nano Letters, 2023

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Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery

Hatit MZC*, Dobrowolski CN*, Lokugamage MP, Loughrey D, Ni H, Zurla C, Da Silva Sanchez AJ, Radmand A, Huayamares SG, Paunovska K, Peck HE, Kim JJ, Sato M, Feldman JI, Rivera MA, Cristian A, Kim Y, Santangelo PJ, Dahlman JE

Nature Chemistry, 2023

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High-throughput screens identify a lipid nanoparticle that delivers mRNA to human tumors in vivo

Huayamares SG*, Lokugamage MP*, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Jong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE.

Journal of Controlled Release, 2023

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Species-dependent in vivo mRNA delivery and cellular response to nanoparticles

Hatit MZC*, Lokugamage MP*, Dobrowolski CN, Paunovska K, Zhao K, Ni H, Vanover D, Beyersdorf J, Peck HE, Loughrey D, Sato M, Cristian A, Santangelo PJ, Dahlman JE.

Nature Nanotechnology, 2022

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Inhibitory oligonucleotides enable programmable non-liver gene editing in adult animals

Sago CD, Lokugamage MP, Lindsay KE, Loughrey D, Hincapie R, Krupczak BR, Kalathoor S, Sato M, Fitzgerald JP, Gan Z, Castro MG, Paunovska K, Sanhueza CA, Hatit MCZ, Finn MG, Santangelo PJ, Dahlman JE.

Nature Biomedical Engineering, 2022

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Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated mRNA delivery

Dobrowolski CN*, Paunovska K*, Echeverri ES, Ni H, Hatit MCZ, Loughrey D, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE.

Nature Nanotechnology, 2022

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Drug delivery systems for RNA therapeutics

Paunovska K, Loughrey D, Dahlman JE.

Nature Reviews Genetics, 2022

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Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo

Ni H*, Hatit MZC*, Zhao K*, Loughrey D, Lokugamage MP, Peck HE, Del Cid A, Muralidharan A, Kim Y, Santangelo PJ, Dahlman JE.

Nature Communications, 2022

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Universal barcoding predicts in vivo ApoE-independent lipid nanoparticle delivery

Da Silva Sanchez A, Dobrowolski C, Cristian A, Echeverri ES, Zhao K, Hatit MCZ, Loughrey D, Paunovska K, Dahlman JE.

Nano Letters, 2022

* Co-first authorship